New Study Links Long-Term Melatonin Use to Increased Heart Failure Risk
A recent study presented at the American Heart Association (AHA) Scientific Sessions 2025 reveals that adults with insomnia who use melatonin for extended periods may face significantly higher health risks. Melatonin, widely used in the United States as an over-the-counter sleep aid, has been linked to serious cardiovascular consequences when used long term.
Key Findings on Melatonin and Heart Failure
- Adults with insomnia using melatonin for at least one year had a 90% greater chance of developing heart failure compared to those who did not use it.
- These users were also nearly 3.5 times more likely to be hospitalized due to heart failure.
- The risk of dying from any cause within five years was considerably higher among long-term melatonin users.
Study Details and Population
Researchers analyzed the health records of over 130,000 adults diagnosed with insomnia but with no prior history of heart failure. The comparison focused on individuals using melatonin for more than a year versus those who never used it.
In the UK, where melatonin is prescription-only, patients with at least two prescriptions filled more than 90 days apart displayed an 82% increased risk of developing heart failure.
Adults with insomnia who took melatonin for at least a year had a much higher chance of developing heart failure, according to researchers.
Compared with similar adults who did not use melatonin, they also have a much greater chance of being hospitalized for it or dying from any cause over the next five years.
Widespread Use and Potential Risks
Melatonin is one of the most commonly used sleep supplements in the United States, with nearly six million Americans relying on it to improve sleep. However, this new evidence emphasizes caution for those considering or currently using melatonin over long periods.
Author’s Summary
Long-term melatonin use in adults with insomnia significantly raises the risk of heart failure, hospitalization, and mortality, highlighting the need for careful medical supervision.