Long-Term Melatonin Use May Increase Heart Risks
Melatonin, commonly used to aid sleep, is generally considered safe, but new research suggests extended use could pose serious heart risks. Chronic users were found to have nearly double the risk of death and were 3.5 times more likely to be hospitalized for heart failure.
Findings from the American Heart Association Study
A preliminary study presented at the American Heart Association’s Scientific Sessions 2025 revealed that adults suffering from chronic insomnia who took melatonin for a year or longer had increased chances of developing heart failure. These participants also showed higher rates of hospitalization due to heart failure and greater overall mortality compared to those not using melatonin.
The study was discussed at the AHA’s annual meeting held from November 7 to 10 in New Orleans, a notable event for cardiovascular research breakthroughs.
About Melatonin
Melatonin is a hormone produced by the pineal gland that controls the sleep-wake cycle, rising naturally in darkness and falling during daylight. Synthetic melatonin supplements, chemically identical to the natural hormone, are widely used to treat insomnia and jet lag.
In many countries, including the United States, melatonin is available over the counter. However, as these supplements are not regulated by U.S. authorities, their purity and dosage can vary significantly between products.
Researchers caution, “Though melatonin is widely regarded as harmless, experts now urge caution with extended use.”
People considering long-term melatonin should weigh the potential cardiovascular risks highlighted by recent findings.
Summary: New research links long-term melatonin use to heightened heart failure risks and mortality, urging caution despite its widespread perception as a harmless sleep aid.