Long-term use of melatonin supplements may carry health risks
Study Overview
A recent review of five years of health data involving more than 130,000 adults with chronic insomnia revealed concerning trends. Individuals who had used melatonin supplements for at least a year showed a higher likelihood of being diagnosed with heart failure, being hospitalized for the condition, and facing increased risk of death from any cause.
Key Findings
The research, to be presented at the American Heart Association’s Scientific Sessions 2025 in New Orleans, suggests a potential link between long-term melatonin use and cardiovascular complications. The study highlights the importance of further investigation into the safety of long-term supplement use.
“Long-term use of melatonin supplements, often used to promote sleep and address insomnia, was associated with a higher risk of heart failure diagnosis, heart failure hospitalization and death from any cause in chronic insomnia.”
Background on Melatonin
Melatonin is a natural hormone produced by the pineal gland that helps control the body’s sleep-wake cycle. Its levels rise at night and drop during the day. Synthetic melatonin, which is chemically identical to the natural hormone, is commonly used to treat insomnia and jet lag.
Supplement Considerations
Melatonin supplements are available over the counter in many countries, including the United States. However, because these products are not subject to government regulation for quality or consistency, their strength and purity can vary widely between brands.
Key Takeaways
- Melatonin use was linked to increased risks of heart failure and all-cause mortality.
- Findings emphasize the need for careful long-term monitoring and research.
- Over-the-counter melatonin supplements differ in quality and dosage consistency.
Author’s Summary
Long-term melatonin use for sleep may raise cardiovascular risks, underscoring the need for medical guidance and better quality control in over-the-counter supplements.