NFL Picks and Predictions for Week 6
The NFL season continues with a highly anticipated slate of games in Week 6. Here are 3 plus-money bets to consider before kickoff.
By Spenser Davis, Published: Oct 12, 2025 · 8:30 AM EDT
Week 6 Predictions
Last week's NFL bold predictions went 2-1, resulting in a total of +1.17 units. Since the start of Week 3, picks in this story are up 2.16 units.
This Week's Bets
One potential strategy is fading the Colts offense, despite their impressive performance. Indianapolis is currently averaging 3.39 points per drive, which would be the highest this century if they maintain this pace all season.
Fading the Colts offense is perhaps not the wisest choice, but I think there’s a case for doing so here.
Author's summary: NFL Week 6 plus-money bets analysis.