UTSA vs. USF Prediction, Betting Odds & How To Watch

The upcoming matchup between South Florida and UTSA carries major implications for both teams in the American Athletic Conference. Despite USF’s recent loss to Memphis that knocked them out of the AP Top 25, the Bulls remain contenders for a spot in the conference championship.

South Florida Overview

The Bulls (6-2, 3-1 American) opened the season strong with impressive wins over ranked opponents Boise State and Florida. After a setback at Miami, they rebounded with four straight victories, three against conference teams. However, a narrow 34-31 defeat to Memphis, sealed by a late Tigers comeback, halted their momentum.

UTSA Overview

UTSA (4-4, 2-2) returned to even record after a decisive 22-point upset victory over Tulane. The Roadrunners began the season with losses to Texas A&M and Texas State but have since won four of their last six, including wins over Incarnate Word, Colorado State, and Rice. They still have hopes of reaching a bowl game and an outside chance at the American title if they can win out.

Game Outlook

“South Florida is a 14-point favorite against UTSA, with the Over/Under set at 67.5. The moneyline lists UTSA at +400 and USF at -550.”

The odds suggest USF’s offensive strength gives them an edge, but UTSA’s recent form could make the contest more competitive than expected.

Players to Watch

USF’s offense, led by their dynamic quarterback and versatile running game.
UTSA’s defense, which has improved across recent games and will aim to slow the Bulls' pace.

Prediction

South Florida’s balance and home-field advantage should carry them through, but UTSA’s resurgence makes this matchup an intriguing one to watch.

Author’s summary: The USF vs. UTSA clash offers crucial conference stakes, with the Bulls favored but the Roadrunners thriving as underdogs on a late-season surge.

HERO Sports — 2025-11-06