The Fragile Flow of Critical Medicines: Rethinking Our Drug Supply Resilience

The Fragile Flow of Critical Medicines: Rethinking Our Drug Supply Resilience

Every hospital shelf and pharmacy counter depends on an invisible global current, the pharmaceutical supply chain. Yet this lifeline for critical medicines is a dangerously thin, fragile network shaped as much by economics and geopolitics as by science, leaving both patients and national security vulnerable when that current falters.

Critical Medicines Are a Matter of National Security

There are approximately 288 critical medicines identified by national and international experts as indispensable for patient care; their absence causes immediate harm.

The World Health Organization defines! "indispensable" with respect to basic healthcare, while our FDA’s criteria are a bit broader.
However, in both instances, these medications have no therapeutic substitutes, or delaying treatment can dramatically worsen outcomes.

Author summary: Global pharmaceutical supply chain is fragile.

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American Council on Science and Health American Council on Science and Health — 2025-10-15

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